What are the effects of unsweetened coffee on the brain and body, according to science?

A Johns Hopkins study published in Nature Neuroscience found that drinking black coffee—without sugar—can boost brain function and support metabolic health. Researchers observed increased neuronal connectivity in the hippocampus, which may improve learning, memory, and attention when coffee is consumed in moderation. They also found that unsweetened coffee can enhance thermogenesis and raise basal metabolic rate, helping support weight-loss efforts alongside a healthy lifestyle.

The study highlights additional benefits: strong antioxidant activity, better vascular protection, and even reduced growth of cavity-causing bacteria—effects that disappear when sugar is added. Experts stress moderation and note that coffee quality and preparation method can influence its benefits.

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