When I was a child, I noticed a peculiar scar on my mother’s upper arm. It was a ring of small indents surrounding a larger one, and though it fascinated me for a time, I eventually forgot about it—like so many fleeting childhood curiosities.Years later, while helping an elderly woman off a train, I caught sight of a similar scar in the exact same spot. It sparked my curiosity anew. With no opportunity to ask the woman about her scar, I called my mother instead. Her response? A revelation that I’d already heard the answer before: the scar came from the smallpox vaccine.
What Was Smallpox?

Smallpox was a highly contagious and often deadly viral disease that plagued humanity for centuries. Caused by the variola virus, it manifested as a fever, followed by a distinctive skin rash that turned into pustules, leaving many survivors disfigured. According to the CDC, during the 20th century, smallpox killed an estimated 30% of those infected.The disease caused devastation on such a scale that it became one of the first targets of a global eradication effort. Thanks to the widespread use of the smallpox vaccine, the disease was declared eradicated worldwide by the World Health Organization (WHO) in 1980. Routine vaccinations in the United States ceased in 1972, as smallpox was already declared extinct in the country by 1952.