The disappearance of Nancy Guthrie, mother of longtime NBC Today co-host Savannah Guthrie, has grown from a private family crisis into a national concern, drawing attention from the White House and prompting President Donald Trump to publicly address the case. Nancy, 84, was last seen at her Tucson-area home on the night of January 31, 2026. Family members became alarmed when she failed to appear at church the next morning, and law enforcement soon discovered troubling signs inside her home, including evidence suggesting forced entry and blood found at the scene. Authorities now believe a crime occurred and say Nancy, who has limited mobility and requires daily medication, likely did not leave on her own. Investigators warn that missing her medication could put her life in immediate danger, increasing urgency around the search.

Sheriff Chris Nanos confirmed that search efforts have shifted from a general missing-person operation to a focused criminal investigation, with detectives reviewing surveillance footage, license plate data, and electronic evidence while urging neighbors to check home security cameras for clues. Officials stress that Nancy is mentally sharp and did not wander off, dismissing speculation about dementia. Meanwhile, Savannah Guthrie publicly thanked supporters and asked for continued prayers as the family awaits answers. President Trump, despite past public clashes with Savannah, expressed concern and said federal resources could be used if needed. Authorities continue appealing to the public for tips, emphasizing that time is critical and that any information, however small, could help bring Nancy home safely while investigators work to uncover what happened.