Christina Applegate has shared a deeply personal update about how multiple sclerosis (MS) continues to affect her health and family life. Diagnosed in 2021, the actress has been candid about the physical and emotional toll of the chronic neurological condition, which impacts the brain and spinal cord. In a recent interview, she revealed that while she treasures taking her daughter to school and activities, most days she must return home and rest in bed due to intense pain and mobility challenges. She described waking up with severe discomfort in her feet and struggling at times to hold everyday items like her phone or a remote. Applegate first noticed symptoms such as numbness in her toes and balance issues during a stressful period in early 2021. Encouraged by fellow actress Selma Blair, who also lives with MS, she sought medical advice and later received her diagnosis.

Beyond MS, Applegate recently faced an additional health setback when she was hospitalized with a serious kidney infection unrelated to her condition. She recounted experiencing intense, radiating pain that led doctors to perform emergency tests before determining the cause. After several days of intravenous antibiotics, she returned home to continue recovering. Through it all, Applegate has remained open about the realities of chronic illness, addressing both the stigma and the unpredictability that come with it. Despite spending much of her time at home, she continues to connect with others through her podcast and public appearances, using her voice to raise awareness and offer solidarity to those facing similar challenges.