Authorities are investigating a deadly UPS cargo plane crash near Louisville Muhammad Ali International Airport that killed 12 people. Early reports indicate the left engine of the MD-11F detached during takeoff on November 4, 2025, causing the aircraft to lose control and crash just beyond the runway. The impact sparked massive fires that spread through nearby buildings.

NTSB spokesperson Todd Inman said the plane, bound for Honolulu, “lifted off and cleared the fence, but shortly after struck terrain off airport property.” CCTV footage confirmed the engine’s separation, and investigators have recovered the black boxes for analysis. The five-ton engine was hurled across the runway, possibly damaging the right wing and triggering the loss of control. Louisville Mayor Craig Greenberg confirmed the victims included three crew members and nine people on the ground. Fifteen families have sought assistance at a reunification center.

The FAA and NTSB are now examining possible maintenance failures or mechanical faults linked to the detachment. Preliminary evidence suggests the engine may have sheared off due to metal fatigue or improper mounting. Kentucky Governor Andy Beshear urged prayers for the victims and advised residents to obey shelter-in-place orders as crews assessed hazardous debris. Dozens of fire and rescue units responded to the inferno, which destroyed several nearby businesses.

Local utility company LG&E reported minor power disruptions, and nearby plants and the Convention Center temporarily halted operations for safety inspections. Flights at Louisville’s airport were suspended as thick black smoke filled the sky. Witnesses described the jet flying unusually low before erupting into a fireball. “It looked like it was trying to climb but just couldn’t,” one resident said. Community leaders and the Muhammad Ali Center expressed condolences, praising first responders for their swift efforts as the investigation continues into this devastating tragedy.