The actor best known for playing Dr. Mark Sloan on Grey’s Anatomy has died at 53 following a battle with ALS, also known as Lou Gehrig’s disease. His family confirmed that he passed away peacefully, surrounded by his wife and two daughters. In their statement, they shared that he spent his final months advocating for ALS awareness and research, expressing gratitude for the support he received from fans around the world. He is survived by his wife, Rebecca Gayheart, and their teenage daughters, Billie and Georgia.

Diagnosed less than a year ago, he had spoken publicly about the progression of the disease, revealing that he had lost function in his arm and was facing increasing physical challenges. ALS is a degenerative condition that affects nerve cells in the brain and spinal cord, gradually leading to loss of muscle control. Beyond Grey’s Anatomy, he also gained recognition for his role in Euphoria and appeared in numerous films and television series throughout his career. He is remembered not only for his on-screen presence but also for his openness, resilience, and dedication to raising awareness during his final chapter.